Alaabta
3,3'- diindolylmethane
Sharaxaada
3,3'-diindolylmethane waa dhexdhexaadiye dawooyin ah;Waxaa laga heli karaa phytochemicals dabiiciga ah oo ay leeyihiin Cruciferae Plants, alaabta falcelinta catalyzed acid, indole-3-methanol;Waxay leedahay shaqada wakiilka ka hortagga burooyinka;Marka la eego xaaladda feejignaanta xad-dhaafka ah, derivative ma aha oo kaliya inay si toos ah u dedejiso apoptosis ee unugyada kansarka bini'aadamka, laakiin sidoo kale dareenka raad raac si ay u kiciso apoptosis ee unugyada kansarka bini'aadamka;Chemicalbookdim waxay keenaysaa xannibaadda giraanta unugga G1 ee kansarka naasaha ee unugyada MCF-7 iyada oo loo marayo habka iyo muujinta ka mid noqoshada;Dim waa horjooge awood leh ee mitochondrial h + -atpase;Dhiirri-geliyaha koritaanka cusub ee dhirta, dim iyo ka-soo-saarkeeda ayaa loo adeegsaday cilmi-baarista nidaamka deegaanka-saaxiibtinimo.
Macluumaadka Alaabta
Cas No.: 1968-05-4
daahirnimo:≥98%
Formula: C17H14N2
Formula Wt.: 246.31
Magaca Kiimikada:3,3'-Diindolylmethane
La mid ah: :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl); Dhirta:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE
Meesha dhalaalaysa:167°C
Barta karkarinta:230C
Solubility: Chloroform (Sparingly), Methanol (wax yar)
Muuqashada: Budada cad-cad
Raridda iyo Kaydinta
Deganaansho Kaydinta Heerkulka kaydinta lagu taliyay -20°C.
Diyaarinta Ku rid indole (1.17 g, 10 mmol), CTAB (50% mol) iyo oxalic acid (50% mol) ku jira 25 ml oo hal luqun ah oo galaas hoose ah, ku dar 5 ml oo biyo ah, si fiican u walaaq 5 min ka dibna ku dar xalinta aqueous formaldehyde (0.38 g xal, 5 mmol formaldehyde) hoos u dhac.Ka fal celi 3 saac heerkulka qolka oo jooji falcelinta.Xalka falcelinta waxaa lagu soo saaray 15 ml of ethyl acetate saddex qaybood, iyo wajiga organic waa la ururiyey oo la qalajiyey Na2SO4 anhydrous saacadaha 5.Walxaha waxa lagu saaray cadaadis hoos u dhacay oo dib ayaa laga sameeyay isku dhafka methanol iyo biyo (methanol/H2ChemicalbookO = 10/1) si loo siiyo cad cad 3,3'-diindolylmethane 85% dhalid.Bioactivity3,3'-Diindolylmethane (DIM) waa sheyga ugu weyn ee dheefshiidka ee indole-3-carbinol, kaas oo ah walaxda ka hortagga kansarka ee khudaarta cruciferous. .
Daraasadaha gudaha ayaa muujiyay in DIM ay tahay ilaaliye wax ku ool ah iyo yaraynta, oo ku dhaqmaysa kicinta ATM-ku-hawlgaliyay jawaabaha DDR-sida iyo sidoo kale NF-κB calaamadaynta badbaadada.DIM waxay joojin kartaa duulaanka unugyada burooyinka, angiogenesis, fidinta iyo kicinta apoptosis iyadoo hagaajinaysa waddooyinka calaamadaha. sida AKT, NF-κB iyo FOXO3.Waxa kale oo ay joojin kartaa muujinta hidda-wadaha estrogen-ku keeno oo ay keento diiqada endoplasmic reticulum.KiimikadabookDIM waxay bedeli kartaa dheef-shiid kiimikaad estrogen waxayna ka soo horjeedaa estrogen iyo dhaqdhaqaaqa soo-qabtayaasha androgen.Daraasadaha vivo waxay muujiyeen in DIM ay wax ku ool u tahay shucaaca nidaamka ka dib maamulo badan.Tijaabada vivo gudaheeda, DIM waxay bixisay ilaalinta shucaaca ama yaraynta.Unugyada caadiga ah, DIM waxay kicisaa ATM.dIM waxaa lagu maamuli karaa jiirarka iyadoo afka laga buuxinayo (250 mg/kg) oo leh bioavailability sare oo aan lahayn t degdeg ah
