Alaabta
Polyinosinic acid-polycytidylic acid
Qaab-dhismeedka
Jireed
Muuqaal: budo cad ama ka baxsan
Cufnaanta
barta dhalaalaysa.
Barta karkarinta.
Refractivity
Barta toosan.
Xogta Badbaadada
Qaybta halista ah.
Lambarka Gaadiidka Alaabta Khatarta ah.
Qaybta xirxirida.
Codsiga
Poly I:C waxaa loo yaqaanaa inay la falgasho lacag-qaade u eg 3 (TLR3), kaas oo lagu muujiyey xuubka endosomal ee unugyada B, macrophages iyo unugyada dendritic.Poly I:C dhisme ahaan waxa uu la mid yahay RNA-da laba-jibbaaran, kaas oo ku jira fayrasyada qaarkood waana kicinta "dabiiciga ah" ee TLR3.Haddaba, Poly I:C waxa loo tixgalin karaa analoogga synthetic ee RNA-da laba-jibbaaran waana aalad caadi ah oo cilmi-baaris cilmiyeed ku saabsan habka difaaca jirka.
Sifada
Alaabtani waa inducer interferon synthetic, kaas oo ah polyribonucleotide labajibbaaran oo ka kooban polyinosinic acid iyo polycytidylic acid.Maadaama interferon uu yahay nooc-gaar ah, way adagtahay in loo diyaariyo tiro badan oo loogu talagalay codsiga kiliinikada, sidaa darteed inta badan waxaa loo isticmaalaa inducer interferon si loo kiciyo interferon.Intaa waxaa dheer, polyinosinic acid weli waxay leedahay doorka difaaca difaaca, taas oo kicin karta nidaamka reticuloendothelial, kor u qaadida shaqada phagocytic ee phagocytes, kor u qaadida samaynta unugyada difaaca jirka, kicinta falcelinta allograft iyo falcelinta xasaasiyadda dib u dhaca.Waxay leedahay saameyn ballaaran oo fayraska ah iyo saameynaha antitumor.
Isticmaalka iyo hababka isku dhafan
Dulmar
Polycytidylic acid, oo sidoo kale loo yaqaano polyinosinic acid, polyhypoxanthine nucleotide iyo polycytidine nucleotide, waa mid ka mid ah polynucleotide, kaas oo ka kooban silsilad polynucleotide ah oo labajibbaaran oo polyinosinic acid iyo polycytidylic acid, oo leh midab-dejin iyo dhibic dhalaal ah, oo deggan -20 ℃ .
Saamaynta dawooyinka
1. Polyinosinic acid waxay saameyn wanaagsan ku leedahay difaac gaar ah iyo kuwa aan gaar ahayn ee jirka.
(1) Polymyocytes waxay kor u qaadaan dhaqdhaqaaqa unugyada difaaca jirka
(2) Polymyocytes waxay kor u qaadaan dheecaanka cytokines kala duwan
(3) Soo-gelinta borotiinka Mx ee polymyocytes
(4) Polymyocytes waxay kor u qaadaan soo saarista unugyada difaaca jirka ee vivo
2. Saamaynta ka hortagga fayraska ee polymyocytes
Tijaabooyinka gudaha vitro, tijaabooyinka xayawaanka iyo tijaabooyinka bukaan-socodka ee bini-aadmiga waxay caddeeyeen in polymyxins ay leedahay saameyno badan oo fayraska ah, oo ay ku jiraan fayraska qandhada jaalaha ah, fayraska encephalomyelitis, fayraska qandhada Rift Valley, fayraska hargabka avian, fayraska cagaarshow, fayraska AIDS, cagta-iyo-afka Fayraska cudurka, fayraska conjunctivitis, fayraska finanka fudud, fayraska Mengo, fayraska pox, fayraska myocarditis, fayraska Aleutian, coxsackievirus, iwm. Waxaa la caddeeyey in ka hortagga Polymyxa uu ka fiican yahay saameynta daaweynta ee caabuqa fayraska.
Codsiga
1.A homopolymer double-stranded kaas oo loo isticmaali karo sida RNA model ah si ay u bartaan calaamadaha unugyada heerka TLR3 aqoonsan double-stranded RNA, kaas oo sidoo kale saamaynta ugu weyn ee jawaab celinta difaaca fayraska fayraska.
2.Labo leh polyinosinic acid si ay u sameeyaan unug polyinosinic, oo loo isticmaalo daawaynta cagaarshowga fayraska, herpes zoster, herpes simplex keratitis, herpes stomatitis, qandhada dhiigbaxa faafa, iwm.
3. Waxay leedahay saameyn difaac difaac ah, waxay kicisaa nidaamka reticuloendothelial, waxay wanaajisaa phagocytosis, waxay wanaajisaa samaynta unugyada difaaca jirka, waxay kicisaa falcelinta allograft iyo falcelinta xasaasiyadda oo daahday.Waxay leedahay saamayn ballaaran antiviral spectrum iyo saamaynta antitumor.Inta badan waxaa loo isticmaalaa kiliinikada: ka hortagga ama daaweynta caabuqyada fayraska, daaweynta herpes zoster, keratitis herpetic, cagaarshowga fayraska.Daaweynta ka hortagga burooyinka.Dareen-celinta xun waxaa ka mid ah hypothermia ku-meel-gaadhka ah iyo xaaladaha gaarka ah ee qandhada sare ee ka sarreysa 38 ℃, taas oo inta badan iskeed u degto 1-2 maalmood gudahood.Haddii qandhadu aysan hoos u dhicin 2 maalmood gudahood, daawada waa in isla markiiba la joojiyo.Waxa kale oo la arkaa daciifnimo, af qallayl, dawakhaad, lallabbo, iwm.
