Alaabta
Dexamethasone
Qaab-dhismeedka
Jireed
Muuqaal: budo cad
Cufnaanta: 1.1283
Meesha dhalaalka: 262-264°C
Barta karkarinta: 568.2±50.0°C
Xogta Badbaadada
Qaybta halista: Alaabta guud
Codsiga
Waxaa inta badan loo isticmaalaa ka hortagga bararka iyo xasaasiyadda.Waxay ku habboon tahay rheumatoid arthritis-ka iyo cudurrada kale ee collagen.
Dexamethasone (DXMS) ayaa markii ugu horreysay la sameeyay 1957 waxaana lagu taxay Liiska Halbeegga Daawooyinka Aasaasiga ah ee WHO oo ah mid ka mid ah daawooyinka lagama maarmaanka u ah nidaamyada caafimaadka bulshada ee aasaasiga ah.
Bishii Juun 16, 2020, WHO waxay sheegtay in natiijooyinka tijaabada caafimaad ee hordhaca ah ee Boqortooyada Midowday ay muujisay in dexamethasone ay badbaadin karto nolosha bukaannada qaba sambabada neocoronary daran, taasoo dhimaysa dhimashada qiyaastii saddex-meelood meel bukaannada hawo-mareennada iyo shan-meelood meel bukaannada buka ogsijiinta kaliya.
Dexamethasone waa corticosteroid synthetic oo loo isticmaali karo in lagu daweeyo xaalado kala duwan, oo ay ku jiraan cudurrada rheumatic, xaaladaha maqaarka qaarkood, xasaasiyad daran, neefta, cudurrada sambabada xanniba ee joogtada ah, laryngitis sax ah, bararka maskaxda, iyo suurtogalnimada in lagu daro antibiyootiga bukaanada qaba qaaxada.Waxay leedahay qiimeynta uurka ee C ee Mareykanka, taas oo u baahan qiimeynta in waxtarka daawadu ka miisaan badan yahay waxyeelada ka hor inta aan la maamulin, iyo qiimeyn A Australia, taas oo muujinaysa in si caadi ah loo isticmaalo haweenka uurka leh. iyo in aysan jirin wax caddayn ah oo muujinaya waxyeellada uurjiifka.
Saamaynta dawooyinka
Dexamethasone, oo sidoo kale loo yaqaan flumethasone, fluprednisolone, iyo dexamethasone, waa glucocorticoid.Alaabooyinkeeda waxaa ka mid ah hydrocortisone, prednisone, iwm. Saamaynta dawooyinka dawooyinka ayaa ah inta badan ka hortagga bararka, sunta, xasaasiyadda iyo ka hortagga laabotooyinka, waxaana si weyn loogu isticmaalaa waxqabadka kiliinikada.Balaasmaheedu T1/2 waa 190 daqiiqo nudaha T1/2 waa 3 maalmood.Xaddiga ugu sarreeya ee dhiigga dexamethasone sodium phosphate ama dexamethasone acetate wuxuu gaaraa saacada l iyo 8 saacadood siday u kala horreeyaan ka dib duritaanka muruqa.Qiyaasta isku xidhka borotiinka balaasmaha ee alaabtani way ka hoosaysaa ta corticosteroids kale.Dhaqdhaqaaqa ka hortagga bararka ee 0.75 mg waxay u dhigantaa 5 mg ee prednisolone.Adrenocorticosteroids, anti-bararka, anti-xasaasiyadda iyo saameynta sunta ayaa ka xoog badan tan prednisone, iyo saameynta xajinta sodium iyo soo saarista potassium waa mid aad u fudud.
1. Saamaynta anti-bararka: Waxay yarayn kartaa oo ka hortagi kartaa jawaabta nudaha ee bararka, sidaas darteed hoos u dhigista muujinta bararka.Hormoonnada ayaa xakameynaya ururinta unugyada bararka, oo ay ku jiraan macrophages iyo leukocytes, goobta caabuqa waxayna joojiyaan phagocytosis, sii daynta enzymes lysosomal, iyo soo saarista iyo sii-deynta dhexdhexaadiyeyaasha kiimikada ee caabuqa.
2. Saamaynta difaaca jirka: oo ay ku jiraan ka-hortagga ama joojinta jawaabaha difaaca unugyada dhexdhexaadka ah, dib-u-celinta xasaasiyadda, yaraynta tirada T lymphocytes, monocytes, iyo eosinophils, hoos u dhigista awoodda isku-xidhka ee immunoglobulins ee soo-dhoweynta dusha unugyada, iyo joojinta isku-darka iyo sii-deynta interleukins , taas oo hoos u dhigaysa beddelka T-lymphocytes ee lymphoblasts iyo hoos u dhigista ballaarinta jawaabaha difaaca aasaasiga ah.Waxay hoos u dhigtaa marinka isku dhafka difaaca jirka iyada oo loo marayo xuubka dhulka hoostiisa waxayna yaraynaysaa fiirsashada qaybaha dhamaystirka iyo immunoglobulins.
Waxaa si sahal ah looga nuugay marinka GI, oo leh balasma T1/2 ee 190 daqiiqo iyo unug T1/2 ee 3 maalmood.Heerarka ugu sarreeya ee dhiigga ayaa la gaaraa 1 saac iyo 8 saacadood ka dib duritaanka muruqa ee dexamethasone sodium phosphate ama dexamethasone acetate, siday u kala horreeyaan.Heerka xidhitaanka borotiinka balaasmaha ee alaabtani way ka hoosaysaa corticosteroids kale, iyo waxqabadka anti-bararka ee alaabtan 0.75 mg waxay u dhigantaa 5 mg ee prednisolone.
