oo Soo saaraha iyo alaab-qeybiyaha wax soo saarka ee Shiinaha Bucladesine |LonGoChem
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Alaabta

Soo-saaraha Shiinaha Bucladesine Sawirka
  • Soo saaraha Shiinaha Bucladesine

Bucladesine

Sharaxaad Gaaban:

Magaca: Bucladesine
Naanaysta: N-6,O-2′-Dibutyryl adenosine cyclic 3′:5′-monophosphate;N-(9-beta-D-Ribofuranosyl-9H-furin-6-yl)-butyramide cyclic 3′,5′-(hydrogen phosphate) 2′-butyrate
Lambarka CAS: 16980-89-5
EINECS lambarka gelitaanka: 241-059-4
Qaaciddada molecular: C18H23N5NaO8P
Miisaanka molecular: 491.37

Faahfaahinta Alaabta

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Guryaha Jirka
Muuqashada: Alaabta cayriin ee cad cad
Xaaladda kaydinta: -20°C
Solubility H2O: 50 mg/ml

Xogta Badbaadada
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Codsiga
Dibutyryl cyclic adenosine monophosphate sodium waa nooc ka soo jeeda cyclic adenosine monophosphate, kaas oo loo isticmaalo daawaynta shoogga wadnaha iyo wadnaha oo shaqayn.1999kii, Dibutyryl cyclic adenosine monophosphate boomaatada sodium ayaa la sameeyay si loo daaweeyo caabuqa maqaarka iyo boogaha maqaarka.

Diyaarinta sodium dibutyryl cyclophosphate adenosine: Gudaha galaaska ay ku jiraan cyclophosphate adenosine si tartiib tartiib ah ugu dar xalinta sodium hydroxide aqueous (3 mol / L) hoos u dhigista, heerkulka habka loo xakameynayo, hoos u dhigista kuleylka heerkulka qolka, hagaaji pH ilaa 7 ~ 8 oo leh xal HCl 20%), ku dar roobka ethanol ee anhydrous ee adag cad, sifaynta, qalajinta si aad u hesho milix cad oo adag oo sodium ah;cusbada sodium-ka iyo n-butyl anhydride iyadoo la ilaalinayo kulaylka N2 ilaa 140 ℃ falcelinta.Kormeerka TLC, falcelintu waa dhammaatay ka dibna hoos ayaa loo dhigayaa heerkulka qolka, si tartiib ah ugu dar methyl tert-butyl ether, habka walaaqinta xoogga leh, Kiimikada si loo helo badeeco cad oo adag oo cayriin ah.Isku darka methyl tert-butyl ether iyo acetone ayaa dib loo hakiyay si loo helo badeeco cad cad oo bartilmaameedsan.Dhaqdhaqaaqa noolahaDibutyryl-cAMP(Bucladesine,dbcAMP) waa unug-falayl-qaade PKA ah kaas oo u dhaqma isagoo la jaanqaadaya cAMP endogenous cAMP.
Daraasadaha gudaha vitro:Dibutyryl-cAMP waxay joojisaa qaadashada gulukooska neerfaha iyadoo loo marayo firfircoonida PKA.Hepatocytes-jiirka dhaqameed, Dibutyryl-cAMP waxay joojisaa muujinta nitric oxide synthase ee aan la dabooli karin iyo NF-kappaB dhaqdhaqaaqa xidhitaanka.dibutyrChemicalbookyl-cAMP sidoo kale waxay joojisaa TNFalpha apoptosis unug usha iyada oo la joojinayo kor u qaadista FADD.
Daraasadaha vivo: Qaabka jiirka, Bucladesine (600nM / mouse, ip) waxay rogtay zinc chloride iyo acetate sunta rasaasta ah oo ay keentay naafanimada xajinta xusuusta.

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