Alaabta
5-Fluorocytosine
Qaab-dhismeedka
Jireed
Muuqaal: budo cad
Cufnaanta: 1.3990 (qiyaas)
Meesha dhalaalka: 298-300 °C (dec.) ( shidday)
Barta karkarinta.
Refractivity
Barta toosan.
Xogta Badbaadada
Qaybta halista ah.
Lambarka Gaadiidka Alaabta Khatarta ah.
Qaybta xirxirida.
Codsiga
Flucytosine afka waxaa loo isticmaalaa daawaynta caabuqyada halista ah ee ay sababaan noocyada u nugul Candida ama Cryptococcus neoformans.Waxa kale oo loo isticmaali karaa daawaynta chromomycosis (chromoblastomycosis), haddii noocyada u nugul ay keenaan caabuqa.Flucytosine waa in aan loo isticmaalin sida wakiilka kaliya ee caabuqyada fangas-ka nafta halis gelinaya sababtoo ah saamaynta antifungal ee daciifka ah iyo horumarka degdega ah ee iska caabinta, laakiin halkii lagu daro amphotericin B iyo/ama azole antifungals sida fluconazole ama itraconazole.Caabuqyada yaryar sida cystitiska candidal waxaa lagu daweyn karaa flucytosine oo keliya.Wadamada qaarkood, daawaynta faleebooyinka xididada oo gaabis ah wax aan ka badnayn toddobaad ayaa sidoo kale ah ikhtiyaar daawaynta, gaar ahaan haddii cudurku yahay mid nafta halis gelinaya.
Caabuqyo fangas oo halis ah ayaa laga yaabaa inay ku dhacaan kuwa difaaca jirkoodu hooseeyo.Dadkani waxay ka faa'iidaystaan daawaynta isku dhafka ah oo ay ku jirto flucytosine, laakiin dhacdooyinka waxyeellooyinka daawaynta isku dhafan, gaar ahaan amphotericin B, ayaa laga yaabaa inay ka sarreeyaan.
5-Fluorocytosine waxaa loo isticmaalaa in lagu daaweeyo caabuqyada fangas ee ay keenaan Cryptococcus iyo Candida, sida fungal sepsis, endocarditis, meningitis, iyo wakiilada antifungal ee caabuqyada sambabada iyo kaadi mareenka.
Sifada
Alaabtani waxay leedahay firfircoonida antifungal sare ee lidka ku ah Candida spp.iyo Candida spp.Waxa kale oo uu leeyahay hawl-bakteeriyo ka dhan ah Bacillus spp.iyo Mycobacterium spp.Badeecadu waa bakteeriyad fiirsi yar iyo fungicidal oo aad u badan.Habka ficilku waa in la xannibo isku-darka nucleic acid fungal.Fungusku way fududahay in la soo saaro caabbinta alaabtan.
Ka taxadaritaan
Marka lagu daro amphotericin B, waxay leedahay saameyn isku mid ah, laakiin waxay yareyn kartaa soo saarista alaabtan kelyaha waxayna kordhisaa diiradda dhiigga, taas oo keeni karta fal-celin sun ah kelyaha iyo habka dhiigga.Sidaa darteed, diiradda dhiigga ugu sarreeya waa in lala socdo oo lagu hayaa 50-75μg / ml, oo aan ka badnayn 100μg / ml;Isticmaalka ka-hortagga dhuuxa lafta waxay kordhin kartaa sunta dhiigga ee alaabtan.
Alaabtani waxay keeni kartaa ① lallabbo, shuban, finan, iwm.;② dhaawaca beerka, inta badan tilmaamayaasha shaqada beerka oo sarreeya, laakiin sidoo kale hepatomegaly ama xitaa necrosis hepatic;③ myelosuppression leukocyte iyo dhimista platelet, marmar waxay keeni kartaa cytopenia dhiiga oo dhan.La'aanta granulocytic leukocyte ee dilaaga ah iyo dhiig-yaraanta soo celisa ayaa sidoo kale la soo sheegay;④ dhalanteed, madax-xanuun iyo vertigo ayaa sidoo kale la soo sheegay.Sidaa darteed, si taxadir leh u isticmaal bukaanada qaba naafo cagaarshow ama kelyaha, xanuunada dhiiga, iyo xakamaynta dhuuxa lafta.Sawirka wareegga dhiigga, shaqada beerka iyo kelyaha iyo kaadida waa in si joogto ah loo fiiriyaa marka la isticmaalayo alaabtan.Waxay saameyn teratogenic ku leedahay baaritaanka xayawaanka, waana in si taxadar leh loogu isticmaalo haweenka uurka leh.
Dareen-celinta xun waxaa ka mid ah transaminases sare, fosfatase alkaline, calaamadaha caloosha iyo mindhicirka, leukopenia, dhiig-yaraan, thrombocytopenia, cillad kelyaha, madax-xanuun, hoos u dhac aragga, dhalanteed, maqal la'aan, dyskinesia, hoos u potassium serum, kalsiyum iyo fosfooraska qiyamka, iyo dareen-celinta xasaasiyadeed (tusaale finan). .
